適用於以下癌症

大腸, 肺, 乳腺, 胃, 肝,

前列腺, 鼻咽, 食道癌

• 僅需 8 毫升血液

• 非侵入性

• 無輻射傷害

• 報告專業快速(5個工作日)

• 比傳統影像檢測敏感度更高，及早跟進

• 比傳統血淸腫瘤標誌物更能反映病情/療效

對象

有家族癌症病史及高危人士:

用處

身體檢測, 及早發現血液循環腫瘤細胞, 及早跟進

對象

剛確診,治療前後,及康復後的患者:

用處

顯示擴散風險,及早配合冶療

輔助評估治療效果,確定治療方案

及早發現復發危機, 即時跟進

CTC檢測是傳統癌症檢測方法的有效補充

好處

傳統方法：

活組織檢驗

成本高,具侵入性
可能有創傷, 檢測次數有限
難以實時檢測癌症擴散

CTC檢測

無創操作
實時檢測
及早反映擴散病况

影像檢查

檢測敏感度受腫瘤大小所限, MRI/PET/CT: 0.3-1cm
研究顯示,每 1cm 的腫瘤裏有過億個癌細胞，因此腫瘤被影像檢查發現時，估计已有過百萬癌細胞

CTC檢測

監測血液中擴散的癌細胞
及早顯示癌症擴散的變化
提供PD-L1 免疫指數及
基因資訊, 配對靶向藥物

血清腫瘤標記物

只是測量分泌的蛋白
凖確度欠佳

CTC檢測

直接凖確檢測腫瘤細胞
直接的擴散證據, 反映病情

References:

1) Pierga JY, etal. Circulating tumor cell detection predicts early metastatic relapse after neoadjuvant chemotherapy in large operable and locally advanced breast cancer in a phase II randomized trial. Clin Cancer Res, 2008. 14(21): p. 7004-10.

2) Bidard FC, etal. Single circulating tumor cell detection and overall survival in nonmetastatic breast cancer. Ann Oncol, 2010. 21(4): p. 729-33.

3) Rack B, etal. Circulating tumor cells predict survival in early average- to- high risk breast cancer patients. J Natl Cancer Inst, 2014. 106(5): dju066.

4) Cristofanilli M, etal. Circulating tumor cells: a novel prognostic factor for newly diagnosed metastatic breast cancer. J Clin Oncol, 2005. 23(7): p. 1420-30.

5) Hayes DF, et al. Circulating tumor cells at each follow- up time point during therapy of metastatic breast cancer patients predict progression-free and overall survival. Clin Cancer Res, 2006. 12(14 Pt1): p. 4218-24.

6) Nole F, etal. Variation of circulating tumor cell levels during treatment of metastatic breast cancer: prognostic and therapeutic implications. Ann Oncol, 2008. 19(5): p. 891-7.

7) Budd GT, et al. Circulating tumor cells versus imaging- - predicting overall survival in metastatic breast cancer. Clin Cancer Res, 2006. 12(21): p. 6403-9.

8) De Bono JS, et al. Circulating tumor cells predict survival benefit from treatment in metastatic castration-resistant prostate cancer. Clin Cancer Res, 2008. 14(19): p. 6302-9.

9) Sun, Y.F., et al., Circulating tumor cells: advances in detection methods, biological issues, and clinical relevance. J Cancer Res Clin Oncol, 2011. 137(8): p. 1151-73.

10) Butler, T. P. and P. M. Gullino (1975). "Quantitation of cell shedding into efferent blood of mammary adenocarcinoma." Cancer Res 35(3):512-516.

11)Chang, Y. S., et al. (2000). "Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood." Proc Natl Acad Sci USA 97(26): 14608-14613.

12) Scott, J. G., et al. (2013). "A mathematical model of tumour self-seeding reveals secondary metastatic deposits as drivers of primary tumour growth." J R Soc Interface 10(82): 20130011.